I've been thinking about the question you're raising for several days now. To me, the answer is non-obvious. Google Cloud has an operating margin of 30.1% (4Q25), but they are hardly an AI pure play. The majority of Google Cloud's revenue, CAPEX, and operating expenses are probably not AI-related. Also, everything about TPUs is expensive. The interconnects (scale-up and scale-out) are proprietary, and I suspect they also use high-margin partners like Broadcom (but I'm not sure who for optical interconnects), so I suspect TPUs and their chassis, racks, and networks are higher cost than AMD's or Nvidia's (even for NVLink and InfiniBand). No one else has enough volume yet to count.
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So, to get back to your question, I think it is not clear that Google Cloud TPUs are more profitable than AMD GPUs.
TPUs are used to mainly drive their internal workloads -- more than the Cloud. TPUs are used to drive the ~$300B in advertising for example.
I'm not sure how an outsider could calculate that ROI or margins.
